Rajeshkumar et al. World Journal of Pharmacy and Pharmaceutical Sciences. ANTICANCER ACTIVITY OF ANDROGRAPHIS PANICULATA. showing anticancer activity on HEp2 – Human larynx carcinoma cell lines in-vitro KEYWORDS: Andrographis paniculata,Herbal medicine. A refined extract of A. paniculata, also significantly reduces activities of lipid .. The anticancer activity was observed due to the presence of andrographolide.

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BioMed Research International

The effects of salinity levels on the measured physiological and phytochemical traits among tolerant and sensitive accessions of A.

After 30 days of culturing almost in 70 days oldthe plants were placed in different salinity levels.

Interestingly, the correlation androographis proline as well as NAG with the other measured morphological characteristics was significant and positive in the salt-stressed plants.

This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cytotoxic effect of Plantago spp. Phenotypic correlation coefficient r among morphological and phytochemical traits in A. Salinity is a major abiotic stress that causes important alterations in the plant growth and development.

As an aerial organ, leaves are directly exposed to various biotic and abiotic stresses, which demand metabolic adaptations for survival.

Indexed in Science Citation Index Expanded. The materials were soaked for three days at room temperature.

ME at the ratio of 1: The colorimetric assay estimated cell number indirectly by staining total cellular protein with the dye SRB. Gour Central University, Sagar M. The following drugs and chemicals were used: It is assumed that the accumulation of these phytochemicals in A.


The stock solution was diluted with anticnacer same solvent to produce different concentration of working standards 0.

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Antkcancer the low level of ahdrographis, the salt activiyy inhibited the biosynthesis of phytochemicals as indicated by the decrease in their amounts in both tolerant and sensitive accessions.

Bounded stain was solubilised with Tris buffer 10 mM and the optical densities were read on an automated spectrophotometric plate reader Molecular Devices, USA at a wavelength of nm, Optical density OD of SRB in each well is directly proportional to the cell number. Analysis of variance showed high significant differences among the accessions for AG and NAG contents. However, we are totally aware that not any correlation does imply causation, yet we believe that in this particular case and according to the previous experiences, our observations are in agreement with the concept of a close relationship between the availability of the secondary metabolites and self-defense systems of the plant species against abiotic stresses.

Fo be clearer, it seems that the accessions with high contents of the anticancer phytochemicals under normal condition would deal more successfully with salinity, as well. Activith marianum is an anticcancer or biennial erect herb belongs to the family Compositae. On the basis of measurement of OD, the anticancer study suggest that S. All chemicals used were of analytical grade.

The filtrate was evaporated to dryness using a rotary evaporator yield was One mL of each standard sample was finally filtered into HPLC vials using the same syringe filters in five replicates [ 4041 ].

Generally, plants produce secondary metabolites in nature as defense mechanisms under different environmental stresses [ 27 ].

The herb exhibited a wide scope of pharmaceutical properties such as anti-HIV [ 19 ], anti-H1N1 [ 20 ], anticancer [ 21 ], antihepatitis [ 22 ], anti-inflammatory [ 23 ], blood purifier, and antidiarrhea [ 24 ]. Plant species react against the environmental changes by producing some secondary metabolites such as soluble anticancr, which protect the cellular structures from oxidative damage and osmotic stress [ 12 ]. In spite of the mentioned trends, the differences between those two accessions were not statistically significant [ 36 ].


Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity Stress

There is a possibility that at the low levels of salinity, the plants might be in the adaptive process against salinity stress due to the osmotic reduction of water anticabcer the root system. Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. In fact, a positive correlation between metabolite enhancement flavonoid and proline and relative water content RWC was reported in rice [ 13 ], reiterating the notion that metabolic adaptations are part of a complex mechanism to overcome threads from stresses.

Prevention of common colds with Andrographis paniculata dried extract: The reduction in sensitive anticancet in terms of all studied morphological traits was higher than in tolerant accessions Figure 1. After 24 h, the cells were treated with the extracts.

The results obtained in the study indicate that A. The relative amounts of phytochemicals in salt-tolerant a and salt-sensitive b accessions of A. How to cite this article: However, the production of the three phytochemicals in A.

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