Water Deprivation Protocol – Biochemistry Departments City Hospital. Indications . Investigation of suspected cranial or nephrogenic diabetes insipidus and. A fluid or water deprivation test is a medical test which can be used to determine whether the patient has diabetes insipidus as opposed to other causes of. The differential diagnosis of diabetes insipidus (DI) is often challenging but essential, 1 October , Pages –, arginine vasopressin determination over the indirect water deprivation test. diagnostic specificity and simplification of the differential diagnostic protocol in DI.

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Our current diagnostic test concepts of DI date back to animal studies from Gilman and Goodman 7576 in the s, which first demonstrated that osmotic stimulation by dehydration 7576 or hypertonic saline infusion 77 induces an antidiuretic urinary response that is not observed in hypophysectomized dogs Celebrating a century of vasopressin therapy. After 2 to 3 hours of cessation of fluid intake, the urine volume and osmolality should reprivation measured every hour and the insipiduz sodium and plasma osmolality every 2 hours.

Under these circumstances, intact thirst sensation is essential to restore normal osmolality, but often at the expense of a clinically pronounced polyuria and polydipsia.

Endocrine Abstracts

Therefore, despite intact pituitary and renal function, patients with PP share essential characteristics of DI. The incidence of long-term DI did not vary significantly between the groups.

Diabetes insipidus and use of desmopressin Minirin during pregnancy. Related articles in Web of Science Google Scholar. A vasopressin analogue in treatment of diabetes insipidus. This leads to dehydration if the patient is not able to keep up with urinary loss and may cause hypernatremia. A controlled, prospective isipidus study.


Early-onset central diabetes insipidus is associated with de novo arginine vasopressin-neurophysin II or Wolfram syndrome 1 gene mutations.

Lithium-induced nephrogenic diabetes insipidus: Lesions of the organum vasculosum of the lamina terminalis OVLT attenuate osmotically-induced drinking and vasopressin secretion in the dog.

The gender difference in the wster of desmopressin has been reported in a study of ODT desmopressin for nocturia and among healthy volunteers. This review covers the physiology of water balance, causes of DI and various treatment modalities available, with a special focus on desmopressin.

Diabetes insipidus: The other diabetes

It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Autosomal recessive familial neurohypophyseal diabetes insipidus: Kauli R, Laron Z. Patients receiving intranasal spray were either switched to desmopressin ODT or continued the nasal spray.

Newly diagnosed patients were treated with desmopressin ODT. For the time being, we consider the water deprivation test followed by a desmopressin challenge as the most plausible test standard to validate the adequacy of AVP function Fig. There are several autosomal recessive forms and X linked recessive forms were described causing DI.

Large genomic aberrations in corticotropinomas are associated with greater aggressiveness. Close mobile search navigation Article navigation.

The manifestation is triggered by the degradation of AVP by the placental enzyme cysteine aminopeptidase 59 — 61although the hormone levels are often normal 62suggesting that pregnancy unmasks a subtle underlying deficiency of AVP 59 Irrespective protoco the cause of diabetes insipidus, whether central or nephrogenic, hereditary or acquired, the consequences are similar as shown in the chart above with loss of free water.


Bendz H, Aurell M. Efficacy and safety of desmopressin orally disintegrating tablet in patients with central diabetes insipidus: The available medications are described in Table 4.

As might be expected, most patients with DI also exhibit a subnormal antidiuretic response to nonosmotic stimuli such as nicotine 96hypotension, nausea, deprivaation hypoglycemia Indomethacin is a nonsteroidal anti-inflammatory drug which has antidiuretic action.

A search of protool on the causes, physiology, and treatment options for DI was carried out using diahetes PubMed database. Biosci Abstracts Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.

Though it is a rare disorder, diabetes insipidus was first described in the 18th century [ 1 ].

Diabetes insipidus: The other diabetes

If compared with the normal physiological relationship between plasma AVP and serum osmolality Fig. Functional characterization of vasopressin receptor 2 mutations causing partial and complete congenital nephrogenic diabetes insipidus in Thai families. Maximal diuresis was achieved in 3—4 days, and the effect was dose-dependent. Development and clinical application of a new method for the radioimmunoassay of arginine vasopressin in human plasma. Apart from lithium multiple medications are associated with nephrogenic DI Table 2.

It usually appears within 24 hours followed by a week period of inappropriate antidiuresis.