Summary. An Orphanet summary for this disease is currently under development. However, other data related to the disease are accessible from the Additional. Pittella JE, de Castro LP. Wernicke’s encephalopathy manifested as Korsakoff’s syndrome in a patient with promyelocytic leukemia. South Med. Wernicke encephalopathy (WE) is an acute neurological condition characterized by a clinical Diekfuss JA, De Larwelle J, McFadden SH.

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Pediatric Neurology Part I. Parenteral administration of thiamine is most effective and provides for rapid administration, however, in some cases, there are persistent neurological deficits, and the acute condition can progress to chronic Korsakoff syndrome.

Thiamine is first metabolised to its more active form, thiamine diphosphate TDPbefore it is used. The Journal of the Association of Physicians sernicke India.

Check this box if you wish to receive a copy of your message. Magnesium and other vitamins should be replaced as well. Show details Treasure Island FL: Neuronal death in the mammillary bodies and thalamus were implicated in multiple cases of Wernicke encephalopathy studied. The reversible cytotoxic dd was considered the most characteristic lesion wetnicke WE.

Because the disorder can present with various manifestations, the patient is best managed by a neurologist and an intensivist.

Considering the slight affectations, previous to the generation of observable lesions at necropsy, the percentage should be higher. European Journal of Neurology. MRI is currently considered the most valuable imaging study available. A typical finding is the bilateral symmetrical T2 abnormal hyperintense signal affecting the periacqueductal gray matter, around the third ventricle and the medial thalamus and the mamillary bodies, 8 which can be found atrophic in a WE that has evolved for more than a week.


Improvement is difficult to quantify because they applied several different actions. The body only has 2—3 weeks of thiamine reserves, which are readily exhausted without intake, or if depletion occurs rapidly, such as in chronic inflammatory states or in diabetes.

Following this an immediate intravenous or intramuscular dose of thiamine should be administered [32] two or three times daily. Summary and related texts. The management of the alcohol withdrawal syndrome and Wernicke encephalopathy. Health care resources for this disease Expert centres 0 Diagnostic tests 0 Patient organisations 0 Orphan drug s 0.

Pellagra Niacin deficiency B 6: The documents contained in this web site are presented for information purposes only.

Thiamine deficiency is characteristically associated with severe alcohol use disorder. Nystagmus is the most common oculomotor dysfunction, and usually is evoked by horizontal gaze to both sides.

These patients are sick, frail and malnourished. Revue neurologique in French. Neither the MR, nor serum measurements related to thiamine are sufficient diagnostic markers in all encefaopatia.

Wernicke encephalopathy – Wikipedia

Korsakoff syndrome is a neuropsychiatric disorder associated with memory disturbances in which there are significant deficits in anterograde and retrograde memory. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted.

Thiamine administration is usually continued until clinical improvement ceases. The authors report the case of a year-old man that during prolonged total parenteral nutrition TPNdue to a bleeding ulcer which required surgery in different occasions, developed a WE, with substantial improvement when intravenous thiamine was administered.

If this is not done, the glucose will rapidly consume the remaining thiamine reserves, exacerbating this condition.

[Wernicke’s encephalopathy and Caine criteria. Report of six cases].

An overview in health and disease” PDF. Japanese Journal of Clinical Oncology. Diagnostic testing encefalopatja not delay treatment. In the clinical diagnosis should be remembered that early symptoms are nonspecific, [33] [34] and it has been stated that WE may present nonspecific findings.


Since many WE patients are managed ehcefalopatia outpatients, the pharmacist should encourage abstinence from alcohol. A year-old man without any relevant medical history was admitted in our Intensive Care Unit with the diagnosis of hemorrhagic shock due to a bleeding ulcer in the first duodenal curve.

Orphanet: Encefalopatia de Wernicke

Wernicke’s encephalopathy during parenteral nutrition. Sarayu Vasan ; Anil Kumar. Other predisposition factors and clinical settings associated to WE and that are commonly encountered in our clinical practice are the hyperemesis gravidarum, gastrointestinal surgery 5 including bariatric surgerysystemic diseases such as encefalopattia and related conditions malignancy is the most common disorder that precipitates a WE in childrensevere infections AIDS, for exampleendocrinological disorders as thyrotoxicosis and also hemo and peritoneal dialysis.

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